- Centre Léon Bérard, Département de Cancérologie Médicale
- Université Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), Inserm U1290
- Réseau d'exploitation des données du système national des données de santé (ReDSiam)
Title of thesis : Effectiveness of immunotherapy rechallenge after toxicity in cancer patients: a target trial emulation based on the French National Health Data System (SNDS).
The EVIRA study aims to assess the effectiveness, safety and efficiency of the immunotherapy rechallenge strategy compared to switching to another treatment among patients with advanced cancers who presented an adverse event leading to immunotherapy discontinuation. In the absence of a randomized clinical trial, this study will be conducted using real-world data from the French National Health Data System (SNDS), with an innovative approach of clinical trial emulation. This study will help identify patients who benefit from rechallenge, improve the management of toxicities, and explore medical practices on a population-wide scale.
Romain Varnier is a medical oncologist and PhD candidate in public health. After completing a medical oncology residency and a Master's degree in public health, he developed methodological expertise in the analysis of real-world data in oncology, particularly data from the French National Health Data System (SNDS). He currently coordinates the "Tumors" group within the ReDSiam network (réseau d'exploitation des données du système national des données de santé), actively contributing to the optimization of health data use for research purposes.
He is pursuing a PhD in public health at the RESHAPE laboratory, with research supported by the ARC Foundation and the French National Cancer Institute. In parallel, he maintains a clinical practice at the Léon Bérard Center, focusing on the management of endocrine cancers, particularly thyroid and adrenal tumors.
