- Hospices Civils de Lyon, Service de médecine du vieillissement, HJ Gériatrique – Programme Bien sur ses jambes, Hôpital Lyon Sud
- Université Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), Inserm U1290
- Université du Québec à Montréal, Faculté des Sciences, Département des Sciences de l’Activité Physique, Montréal, Qc, Canada
Titre de la thèse : Étude de composantes de la mobilité et implications dans les stratégies de prévention ciblées chez le senior.
Year of registration : 2024
Directeurs : Dr Thomas Gilbert, Pre Mylène Aubertin-Leheudre, Pr émérite Marc Bonnefoy
Summary of the thesis : One of the main challenges of prevention in aging is to avoid falls, loss of mobility and associated geriatric syndromes (sarcopenia and frailty). It is now well established that exercise is an effective prevention strategy. However, it is imperative to define the target profiles of these exercise programs to optimize training adaptations and exercise prescription. To address this issue, an exercise program aimed at preventing loss of mobility and falls and entitled “Bien sur ses jambes” (Well on your legs) was created at Hospices Civils de Lyon in 2014. This pragmatic program is implemented following 6 steps, 1) screening, 2) pluridisciplinary assessment (medical, nutritional and physical), 3) for people at risk, integration into a supervised group exercise program for 10 weeks (2x/week, 1h, 6-8 people/group), 4) reassessment, 5) relay intervention proposal, 6) motivational telephone interview 6 months after reassessment and 1-year follow-up.
This project will include several retrospective and prospective studies. Using a large cohort, we will analyze training adaptations according to different participant profiles on mobility parameters. To do so, we will first investigate the influence of obesity, with or without dynapenia. Secondly, we will investigate the influence of fall history and fear of falling. In a 3rd study, we will analyze the influence of level grouping (according to participants' physical abilities and state of health) on training adaptations. A final study will characterize changes in mobility parameters at 1 year and identify profiles at risk of losing benefits.
Improving our knowledge of the effectiveness of prevention strategies is an essential step towards facing the challenge of healthy aging.
1. Delaire L , Courtay A , Humblot J , Aubertin-Leheudre M , Mourey F , Racine AN , Gilbert T , Niasse-Sy Z , Bonnefoy M. (2023). Implementation and Core Components of a Multimodal Program including Exercise and Nutrition in Prevention and Treatment of Frailty in Community-Dwelling Older Adults: A Narrative Review. Nutrients. 15(19). DOI: 10.3390/nu15194100. https://pubmed.ncbi.nlm.nih.gov/37836384/
2. Delaire L , Courtay A , Pageaux B , Gautier C , Rayon FJ , Mourey F , Racine AN , Humblot J , Bonnefoy M. (2023). [Conducting a multimodal exercise program in primary and secondary prevention of mobility disabilty in older adults at risk: guidelines and practical applications]. Geriatrie et psychologie neuropsychiatrie du vieillissement. 21(1): 37-50. DOI: 10.1684/pnv.2023.1084. https://pubmed.ncbi.nlm.nih.gov/37115678/
3. Bres E , Bouvier J , Courtay A , Delaire L , Humblot J , Cuerq C , Tripoz-Dit-Masson S , Fauvernier M , Gilbert T , Bonnefoy M. (2023). FGF19 and muscle architecture in older patients. Experimental gerontology. 174: 112120. DOI: 10.1016/j.exger.2023.112120. https://pubmed.ncbi.nlm.nih.gov/36764368/
4. Payen de la Garanderie M , Courtay A , Féral-Basin C , Rainville P , Gaveau J , Pageaux B. (2022). Perception of effort and the allocation of physical resources: A generalization to upper-limb motor tasks. Frontiers in psychology. 13: 974172. DOI: 10.3389/fpsyg.2022.974172. https://pubmed.ncbi.nlm.nih.gov/36760904/
5. Delaire L, Courtay A, Fauvernier M, Humblot J, Bonnefoy M. (2021). Integrating a Prevention Care Path into the Daily Life of Older Adults with Mobility Disability Risk: Introducing a Predictive Response Model to Exercise. Clinical Interventions in Aging. 16: 1617-1629. DOI: 10.2147/CIA.S315112. https://pubmed.ncbi.nlm.nih.gov/34531652/
